I dont think shes dead ive heard many suggestions to what could have happened includeing that she will heal herself as the the apple touches her cause the apple is let go out of desmonds hands. The next game i think is going to focus on the american revolution cause there were a lot of hints at the end of brotherhood. That eye symbol which is supposed to be on their money showed up and some think think the next game could be about the freemasons as they have a hugely similar logo if you google them to the assassins logo which could be a clue. France was also suggested to be a possible location staying in europe but i would think they would want to enter a different part of the world since they have already done the middle east and europe. Cant wait for the game i just hope it lives up to expectation cause i didnt believe the last was as good as AC II.